William Seibel Selected Research

SBI-0206965

10/2022

Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma.

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William Seibel Research Topics

Disease

5	Neoplasms (Cancer) 01/2022 - 01/2013
3	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2020 - 04/2015
2	Glioblastoma (Glioblastoma Multiforme) 10/2022 - 03/2018
2	Carcinogenesis 01/2022 - 09/2013
2	Retinal Degeneration 01/2018 - 01/2015
2	Neoplasm Metastasis (Metastasis) 09/2017 - 09/2013
2	Breast Neoplasms (Breast Cancer) 09/2017 - 06/2012
1	Brain Neoplasms (Brain Tumor) 10/2022
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022
1	Multiple Sclerosis 01/2019
1	Adenocarcinoma of Lung 03/2018
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 03/2018
1	Ovarian Neoplasms (Ovarian Cancer) 03/2018
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2017
1	Neuralgia (Stump Neuralgia) 09/2013
1	Pruritus (Itching) 09/2013
1	Infections 08/2013
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2013
1	Lung Neoplasms (Lung Cancer) 01/2013
1	Inflammation (Inflammations) 02/2012
1	Neurofibrosarcoma (MPNST) 09/2011
1	Melanoma (Melanoma, Malignant) 06/2009

Drug/Important Bio-Agent (IBA)

3	Pharmaceutical PreparationsIBA 01/2022 - 01/2015
2	Rhodopsin (Visual Purple)IBA 01/2020 - 01/2018
2	Neurofibromin 1 (Neurofibromin)IBA 03/2018 - 09/2011
1	Adenosine Monophosphate (AMP)IBA 10/2022
1	Protein Kinases (Protein Kinase)IBA 10/2022
1	AMP-Activated Protein KinasesIBA 10/2022
1	SBI-0206965IBA 10/2022
1	Rho Guanine Nucleotide Exchange FactorsIBA 01/2022
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2022
1	Tyrosine (L-Tyrosine)FDA Link 01/2022
1	GTP Phosphohydrolases (GTPases)IBA 01/2022
1	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 01/2022
1	Superoxides (Superoxide)IBA 03/2018
1	Rod OpsinsIBA 01/2018
1	Adenosine Triphosphatases (ATPase)IBA 09/2017
1	Proton Pumps (Proton Pump)IBA 09/2017
1	Therapeutic UsesIBA 09/2017
1	Adenosine Triphosphate (ATP)IBA 09/2017
1	OpsinsIBA 04/2015
1	Retinaldehyde (Retinal)IBA 01/2015
1	retinylamineIBA 01/2015
1	LipidsIBA 09/2013
1	alkylglycerophosphoethanolamine phosphodiesteraseIBA 09/2013
1	lysophosphatidic acidIBA 09/2013
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2013
1	Heparin (Liquaemin)FDA LinkGeneric 01/2013
1	MidkineIBA 01/2013
1	rhosinIBA 06/2012
1	Nerve Growth Factor (NGF)IBA 06/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2012
1	NADPH Oxidases (NAD(P)H oxidase)IBA 02/2012
1	EnzymesIBA 02/2012
1	LigandsIBA 06/2009
1	ThiazolesIBA 06/2009

Therapy/Procedure

7	Therapeutics 01/2022 - 09/2011
1	Critical Care (Surgical Intensive Care) 08/2013